NQ20TM

- Water-soluble (stably water-dispersible) CoQ10 powder.

- NQ20TM enables the enhanced bioavailability of CoQ10 and convenient incorporation of CoQ10 into various types of functional foods including beverages.

- For cosmetics, NQ20TM allows CoQ10 to be incorporated into various types of water-based products in high concentration.

Features: Orange Powder, Water-soluble (Stably dispersible in nanoparticles)

Spec: 20% of CoQ10 and 80% of FDA approved inactive ingredients

Water-dispersible CoQ10 powder

20% of CoQ10 + FDA approved inactive ingredients

Easily dispersible in water with high concentration

Widely applicable to various types of water-based products including beverages or cosmetic products

50mg/ml,5mg/ml,1mg/ml,0.5mg/ml

Bioavailability enhancement of NQ20TM (In-vivo testing)

A preclinical study was conducted to verify the bioavailability increase of NQ20TM. The AUC of the NQ20TM group was about twice of the AUC of the normal CoQ10 group and even a little better than that of the group administered with CoQ10 dissolved in corn oil.

The Challenge of Poor Solubility

- The water solubility of active pharmaceutical or nutraceutical ingredients is a key property governing dissolution, absorption, and in-vivo efficacy.

- Poor water solubility makes it difficult to incorporate active ingredients into water-based pharmaceutical, nutraceutical, or cosmetic products

-There are many approaches to address the challenge

? Particle size reduction

? Modification of polymorphs

? Drug suspension in carriers (e.g. solid dispersion)

? Use of complexing agents

? Solubilization by surfactants (e.g. microemulsion, SMEDDS)

The approach of Bio-Synectics

- The solution of Bio-Synectics for the poor solubility problem is to decrease the particle sizes of active ingredients to nanometer range

- The platform technologies of Bio-Synectics generate nano-sized particles efficiently for many poorly soluble ingredients

- The technologies of Bio-Synectics have the following advantages

?There is no burden of additional safety issues, as we are not using any special carriers to make nanoparticles and only use safe materials generally used in the industries

?They provide powder form outputs, which can be directly used for subsequent processes without typically needed drying steps of other nanoparticle technologies.

The Advantage of Nanoparticulation

- Enhanced bioavailability of orally administrated poorly soluble active ingredients

?Increased dissolution velocity allows enhanced bioavailability

?Decreased fed/fasted and inter-individual variations

- Improved formulation flexibilities

?By making colloidal particle dispersions, stable aqueous formulations can be developed

?The water-dispersion of nanosized particles provides convenient formulation solutions to incorporate poorly soluble ingredients into various types of functional food products or cosmetic products.